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As more consumers have turned to online shopping since the COVID-19 pandemic, communication through offline channels has also entered a new phase. Young consumers recognize offline channels as a play space for enjoying various experience elements. Applying Pine and Gilmore's (1998) experiential economy theory, this study initially explores the structure of experience factors in the context of experiential fashion stores (RQ1). Next, we investigate the effect of experience factors on consumer loyalty by mediating store attachment (RQ2). In addition, the moderating effect of fashion innovativeness was verified (RQ3). This survey targeted members of the MZ generation who have visited experiential fashion stores. A total of 225 survey responses were analyzed using AMOS 22.0 and SPSS 26.0. First, as a result of factor analysis, the experience factors of experiential fashion stores were classified into education, escapism, and aesthetic entertainment. Secondly, as a result of structural equation modeling (SEM), all three experience factors positively affected store attachment, and increased attachment positively enhanced consumer loyalty. Finally, as a result of multigroup SEM analysis, consumers with low fashion innovativeness considered educational experience as an important factor in inducing store attachment, while consumers with high fashion innovativeness value escapism and aesthetic entertainment experiences. © 2023, The Korean Society of Clothing and Textiles. All rights reserved.
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The spread of COVID-19 has resulted in several changes worldwide. In particular, border closures and economic stagnation have significantly affected societies. Although the implementation of preventive measures has improved the pandemic scenario in several countries, the effectiveness of vaccines has decreased with the emergence of mutant viruses. With this background, the use of masks is considered the best method for preventing the spread of the virus. Notably, public transportation is closely related to socioeconomic activities, and the spread of infectious diseases is more likely in closed, dense, and congested areas. Moreover, the probability of infection during public transportation also depends on the proportion of commuters wearing masks. Based on the closed-circuit television footage of various public transportation spaces, the number of mask wearers can be analysed using artificial intelligence deep learning, and the probability of COVID-19 spread can be predicted by determining the proportion of mask wearers among the commuters. With this background, in this study, the importance of masks in controlling the spread of the virus is confirmed. In conclusion, appropriate measures can be implemented by determining the probability of infection according to the mask-wearing rate in public transportation spaces. © 2023 ICE Publishing: All rights reserved.
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As COVID-19 has been prevalent around the world in recent years, many studies about monitoring and predicting the spread of disease have been conducted in various fields including geography. However, little research has been devoted to infectious disease prediction modeling that adopts constantly changing travel behavior patterns during epidemics. This is due to the limited methodologies to investigate spatio-temporal change in travel behaviors at large-scale and the difficulty in interpreting massive and diverse travel patterns. This study suggests an effective disease surveillance method based on cluster analysis to identify change in travel behaviors during the pandemic by implementing space-time cluster analysis. The results show that K-means++ well represent dynamic changes in travel behaviors at daily scale, whereas retrospective space-time scan statistics have the advantage of detecting travel behavior changes in each period at large spatial scale. Those results could inform decision makers to establish guidelines on travel behavior to curb individual contacts under potential future pandemic. © 2023 Korean Society of Surveying. All rights reserved.
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Coronavirus disease (COVID-19) has significantly affected daily lives since its declaration as a Pandemic in March 2020 by the WHO. Studies in Korea to interpret the relationship between COVID-19 and transportation show that there has been a decrease in public transportation use, and a significant decrease when a widespread infection occurs. In addition, COVID-19 has affected the commercial environment, particularly the number of people using commercial districts where the use of retail outlets decreased significantly. This study analyses the disease-vectors (spread factors) of COVID-19 in terms of transportation demand, the revitalisation of commercial districts, living populations, and socioeconomic indicators. It attempts to identify different infection factors for each district in Seoul using a causal analysis methodology PLS-SEM (Partial Least-Squares Structural Equation Modelling) such that COVID-19 can be managed continuously with the aim to provide a foundation for pre-emptive actions by adjusting or controlling specific influencing factors pertaining to infectious diseases. © 2023 ICE Publishing: All rights reserved.
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OBJECTIVE: During the COVID-19 pandemic, many research studies were adapted, including our longitudinal study examining cognitive impairment (CI) in systemic lupus erythematosus (SLE). Cognitive testing was switched from in-person to virtual. This analysis aimed to determine if the administration method (in-person vs. virtual) of the ACR-neuropsychological battery (ACR-NB) affected participant cognitive performance and classification. METHODS: Data from our multi-visit, SLE CI study included demographic, clinical, and psychiatric characteristics, and the modified ACR-NB. Three analyses were undertaken for cognitive performance: (1) all visits, (2) non-CI group visits only and (3) intra-individual comparisons. A retrospective preferences questionnaire was given to participants who completed the ACR-NB both in-person and virtually. RESULTS: We analysed 328 SLE participants who had 801 visits (696 in-person and 105 virtual). Demographic, clinical, and psychiatric characteristics were comparable except for ethnicity, anxiety and disease-related damage. Across all three comparisons, six tests were consistently statistically significantly different. CI classification changed in 11/71 (15%) participants. 45% of participants preferred the virtual administration method and 33% preferred in-person. CONCLUSIONS: Of the 19 tests in the ACR-NB, we identified one or more problems with eight (42%) tests when moving from in-person to virtual administration. As the use of virtual cognitive testing will likely increase, these issues need to be addressed - potentially by validating a virtual version of the ACR-NB. Until then, caution must be taken when directly comparing virtual to in-person test results. If future studies use a mixed administration approach, this should be accounted for during analysis.
Subject(s)
COVID-19 , Lupus Erythematosus, Systemic , Rheumatology , Humans , United States , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/psychology , Retrospective Studies , Longitudinal Studies , Pandemics , COVID-19/complications , CognitionABSTRACT
The travel industry has been severely affected by the COVID-19 outbreak. The operating pressure on enterprises has sharply increased, leading to the prominent phenomenon of abusive supervision. Managers employ this management method so that employees perceive work pressure as motivation to work harder and improve their performance. Employees may adopt the behavior of defensive silence to protect themselves from abusive supervision, which can subsequently affect employee behavior. However, social capital and relationships may lessen this effect. This study analyzed survey data on 475 workers from the Chinese tourism service industry to examine the mediating role of workers' defensive silence under abusive supervision, employee behavior, and the moderating role of social capital. The results showed that abusive supervision does not promote employee performance but hinders employee growth. Employees' defensive silence also affects employee behavior and has a partially mediating role in the relationship between abusive supervision and employee behavior. Social capital can mitigate the negative impact of abusive supervision on employee behavior. This study theoretically expands the applicable scope of employee silence as a mediating variable and social capital as a moderating variable. It is helpful for managers to change their negative leadership style, follow the suggestions of employees, pay attention to the organizational atmosphere, and enhance their team cohesion. © 2023 by the authors.
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Since the main symptoms of COVID-19 involve the respiratory system, the infection rate of this disease is predicted to be higher in patients with other respiratory conditions such as allergic rhinitis. In such a situation, it will be meaningful to conduct research on an allergy treatment that has fewer side effects and can effectively reduce allergy symptoms. Here, we prepared experimental samples under various fermentation conditions with mixed extracts of six medicinal plants. To examine the anti-allergic efficacy of these samples, an egg albumin-induced allergic rhinitis animal model experiment, a serum histamine and IgE experiment, and a COX and LO inhibitory activity experiment were conducted. As a result of animal experiments, OVA+SP-4 showed superior efficacy compared to OVA+SP-1 in nasal rubbing and sneezing experiments and had anti-allergic efficacy similar to that of OVA-cetirizine. The serum histamine concentration of OVA+SP-4 was also 1.3 times higher than that of the OVA+cetirizine group, showing a high histamine reduction ability, and IgE showed the same trend. An analysis of COX inhibitory efficacy also confirmed that COX-1 and COX-2 inhibitory efficacy is high, and the longer the fermentation time, the higher the antiallergic efficacy. The composition proposed by this study is expected to have a significant effect on sustainable allergy prevention and treatment in the future by applying it to human patients. Copyright © 2022, The Korean Society for Microbiology and Biotechnology.
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This study aimed to explore the collaborative creative process within the group by designing and executing music creation activities using digital media. Qualitative data such as class observation videos, website data, interviews, reflection essays, mind maps, and worksheets were collected from 50 fifth graders in elementary school, and qualitative data analysis was conducted through two-stage coding process. As a result of the study, 'integration' and 'selection' were found as strategies for the cooperation process within the group. Both 'integration' and 'selection' were rules and strategies agreed upon by members within the team for collaborative creation. In addition, discussions regarding changes in students' 'confidence' due to 'emotional support' as a factor affected students' attitudes in the creative process in the group. Through this study, the significance of collaborative music creation activities in the field of public elementary education and the strategy of practical music creation classes in post COVID-19 era were presented. © 2022 Korean Music Education Society.
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Background: As COVID-19 is associated with a prothrombotic condition and some critically ill patients may even undergo extracorporeal oxygenation treatment, heparin is the essential for treatment in these situations. The prevalence of anti-platelet factor 4 (PF4)/heparin antibodies associated with thrombotic tendency may be present in patients hospitalized for COVID-19 without heparin therapy. Lupus anticoagulant (LA) included in the diagnostic criteria for antiphospholipid syndrome, which is one of the common causes of thrombophilia, is also commonly detected during SARS-CoV- 2 infection. Most patients hospitalized for COVID-19 showed elevated D-dimer and prolonged activated partial thromboplastin time (aPTT), However, there were no studies on the association of SARS-CoV- 2 infection with LA and anti-PF4/ heparin antibodies. Aim(s): The purpose of this study was to analyze the expression of LA and anti-PF4/ heparin antibodies associated with thrombotic tendency in COVID-19 patients. Method(s): We performed LA test (Instrumentation Laboratory, Bedford, MA) and LIFECODES PF4 IgG assay (Immucor, Norcross, GA) on 46 COVID-19 patients admitted to Asan Medical Center and analyzed their frequency. Result(s): Of a total of 46 COVID-19 patients, 26 patients (56.5%) were positive for LA test, 3 patients (6.5%) for anti-PF4/ heparin antibodies. In particular, anti-PF4/ heparin antibodies was detected only in LA-negative patients and showed low optical density values (3 out of 20 LA-negative patients, 15.0%). All three patients positive for anti-PF4/ heparin antibodies had no history of heparin treatment. Conclusion(s): In COVID-19- patients, anti-PF4/ heparin antibody test does not predict clinically relevant HIT antibodies. Anti-PF4/ heparin antibodies appear in LA-negative COVID-19 patients, so they are carefully expected to serve as LA-independent indicators. (Table Presented).
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Purpose: Mortality from COVID-19 among kidney transplant recipients (KTR) is unacceptably high, and their response to up to three vaccinations against SARSCoV- 2 is strongly impaired. We provide the first systematic analysis of serological response to up to five repeated vaccinations in nonresponding KTR. Method(s): We retrospectively analyzed serological response to basic immunization, as well as administration of three, four and five doses of SARS-CoV-2 vaccine in KTR from December 27, 2020 until December 31, 2021. In particular, the influence of different dose adjustment regimens for mycophenolic acid (MPA) on serological response to fourth vaccination was analyzed. Result(s): In total, 4.277 vaccinations against SARS-CoV-2 in 1.478 patients were analyzed. Serological response was 19.5% after 1.203 basic immunizations, and increased to 29.4%, 55.6%, and 57.5% after 603 third, 250 fourth and 40 fifth vaccinations, resulting in a cumulative response rate of 88.7% (figure 1A-B). Patients with belatacept immunosuppression show impaired cumulative serological response (4.4%, 12.4%, and 16.4%) in comparison to patients with calcineurin inhibitor (CNI)- based immunosuppression (19.1%, 37.6%, and 70.1%) after basic immunization, three, and four vaccinations (figure 1C-F). In patients with CNI and MPA maintenance immunosuppression, pausing MPA and adding 5 mg prednisolone equivalent before the fourth vaccination increased serological response rate to 75% in comparison to no dose adjustment (52%) or dose reduction (46%) without occurence of rejections (figure 2). Conclusion(s): Repeated SARS-CoV-2 vaccination of up to five times effectively induces serological response in kidney transplant recipients. It can be enhanced by pausing MPA at the time of vaccination. Patients with belatacept immunosuppression are unlikely to achieve sufficient serological response and require different approaches.
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The COVID-19 pandemic has created significant developments in the year since 2020, particularly in the worldwide tourist sector. Tourist-related sectors have suffered significant damage, with China's domestic tourism industry in critical condition. Not only did this industry's income plummet, but allied businesses such as restaurants and transportation also experienced significant losses. This unprecedented public health crisis, marked by its suddenness, intensity of injury, and uncertainty about future development, has had a massive impact on a wide variety of individuals. This article depicts the influence of COVID-19 on China's tourist business, taking into consideration the industry's present development before and after the pandemic. Using Ctrip (a Chinese tourism company) as an example, this paper employs the case analysis method to examine Ctrip's operational capabilities, organizational leadership, and organizational culture as embodied in its fight against the pandemic, as well as its handling measures in the face of the tourism crisis. Finally, several ideas are proposed to promote tourism development in the post-pandemic era: integrating the digital economy and promoting the innovative development of digital tourism;changing business mindsets to make the relevant industrial chain bigger and stronger;establishing a regular management organization to deal with tourism crises and improving the tourism crisis management mechanism. This study may be useful for future tourism enterprises' response plans in the event of a public health crisis. © 2022, Success Culture Press. All rights reserved.
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The SARS-CoV-2 omicron variant presented significant challenges to the global effort to counter the pandemic. SARS-CoV-2 is predicted to remain prevalent for the foreseeable future, making the ability to identify SARS-CoV-2 variants imperative in understanding and controlling the pandemic. The predominant variant discovery method, genome sequencing, is time-consuming, insensitive, and expensive. Ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) offers an exciting alternative detection modality provided that variant-containing peptide markers are sufficiently detectable from their tandem mass spectra (MS/MS). We have synthesized model tryptic peptides of SARS-CoV-2 variants alpha, beta, gamma, delta, and omicron and evaluated their signal intensity, HCD spectra, and reverse phase retention time. Detection limits of 781, 781, 65, and 65 amol are obtained for the molecular ions of the proteotypic peptides, beta (QIAPGQTGNIADYNYK), gamma (TQLPSAYTNSFTR), delta (VGGNYNYR), and omicron (TLVKQLSSK), from neat solutions. These detection limits are on par with the detection limits of a previously reported proteotypic peptide from the SARS-CoV-2 spike protein, HTPINLVR. This study demonstrates the potential to differentiate SARS-CoV-2 variants through their proteotypic peptides with an approach that is broadly applicable across a wide range of pathogens.
Subject(s)
COVID-19 , SARS-CoV-2 , COVID-19/diagnosis , Chromatography, Liquid , Humans , Peptides/chemistry , Peptides/genetics , SARS-CoV-2/genetics , Spike Glycoprotein, Coronavirus , Tandem Mass SpectrometryABSTRACT
Purpose: Especially with the COVID19 pandemic, the necessity of technology-based interventions using computers and mobile devices has increased in cancer survivorship management including symptom management. However, little is known about the effectiveness of a technology-based intervention in improving symptom experience of racial/ethnic minorities including Asian American breast cancer survivors. The purpose of this study was to examine the efficacy of a technologybased intervention in improving symptom experience of Asian American breast cancer survivors. Methods: This study was conducted as a part of an ongoing randomized clinical trial among 199 Asian American breast cancer survivors. The technology-based intervention included three subethnic specific social media sites, interactive online educational sessions, and online resources. Both groups (intervention and control groups) used the American Cancer Society's website on breast cancer, and only the intervention group used the technology-based intervention. Only the data collected using the questionnaire on background characteristics and health/disease status and the Memorial Symptom Assessment Scale-Short Form (MSAS) were analyzed for this study. The data were analyzed using separate intent-to-treat growth curve models. Results: While both groups reported decreases in symptom scores from the pre-test to post 3- months (p<.01), the intervention group had larger decreases in symptom scores compared with the control group (p<.01). There existed significant group∗time interactive effects on the Global Distress Index (β = - 0.234), the Physical Symptom Distress scores (β = -0.266), the psychological symptom distress scores (β = - 0.212c), the total number of symptoms (β = -0.261), and the total symptom distress scores ( β = -0.261). Conclusions: The findings of this study clearly indicated symptom improvement among Asian American breast cancer survivors by a technology-based intervention using computers and mobile devices. Further studies with diverse racial/ethnic minorities are warranted to confirm the effectiveness of technology-based interventions in improving symptom experience of cancer survivors across different types of cancer.
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Purpose: To evaluate the efficacy and safety of coronavirus disease 2019 (COVID-19) vaccines in children aged 5–11 years, a rapid systematic review was conducted on published clinical trials of COVID-19 vaccines and studies that analyzed real-world data on adverse events after COVID-19 vaccination. Methods: A systematic search was conducted on medical literature in international (Ovid-MEDLINE) and pre-published literature databases (medRxiv), followed by handsearching up to January 4, 2022. We used terms including COVID-19, severe acute respiratory syndrome coronavirus 2, and vaccines, and the certainty of evidence was graded using the GRADE approach. Results: A total of 1,675 studies were identified, of which five were finally selected. Among the five studies, four consisted of data from clinical trials of each of the four types of COVID-19 vaccines (BNT162b2, mRNA-1273, CoronaVac, and BBIBP-CorV). The remaining study consisted of real-world data on the safety of the BNT162b2 vaccine in children aged 5–11 years. This systematic review identified that COVID-19 vaccines in recipients aged 5–11 years produced a favorable immune response, and were vaccines were effective against COVID-19. The safety findings for the BNT162b2 vaccine in children and early adolescents aged 5–11 years were similar to those data noted in the clinical trial. Conclusions: There is limited data on COVID-19 vaccines in children aged 5–11 years. Consequently continuous and comprehensive monitoring is necessary for the evaluation of the safety and effectiveness of the COVID-19 vaccines.